Opioid-induced chemokine expression requires NF-κB activity: the role of PKCζ.

@article{Happel2011OpioidinducedCE,
  title={Opioid-induced chemokine expression requires NF-κB activity: the role of PKCζ.},
  author={Christine Happel and Michele A. Kutzler and Thomas J Rogers},
  journal={Journal of leukocyte biology},
  year={2011},
  volume={89 2},
  pages={301-9}
}
Opioid receptor agonists induce broad immunomodulatory activity, which substantially alters host defense and the inflammatory response. Previous studies have shown that the MOR selective agonist DAMGO has the capacity to increase the expression of the proinflammatory chemokines CCL2, CCL5, and CXCL10 in human PBMCs. NF-κB is a transcription factor that… CONTINUE READING