Opioid efficacy is linked to the LiCl-sensitive, inositol-1,4,5-trisphosphate-restorable pathway.

@article{Raffa1992OpioidEI,
  title={Opioid efficacy is linked to the LiCl-sensitive, inositol-1,4,5-trisphosphate-restorable pathway.},
  author={R B Raffa and Caroline Connelly and Rebecca P Martinez},
  journal={European journal of pharmacology},
  year={1992},
  volume={217 2-3},
  pages={221-3}
}
Previous work demonstrated that a single subcutaneous injection of LiCl (10 mmol/kg; 18 h prior) significantly reduces the antinociceptive action of centrally administered (intracerebroventricular; i.c.v.) morphine in the tail-flick and that inositol-1,4,5-trisphosphate (IP3; 20 micrograms) restores the morphine response in LiCl-pretreated mice, implicating… CONTINUE READING