Opioid effects on mitogen-activated protein kinase signaling cascades.

@article{Gutstein1997OpioidEO,
  title={Opioid effects on mitogen-activated protein kinase signaling cascades.},
  author={Howard B. Gutstein and Elizabeth A. Rubie and Ali E. Mansour and Huda Akil and James R Woodgett},
  journal={Anesthesiology},
  year={1997},
  volume={87 5},
  pages={1118-26}
}
BACKGROUND The molecular mechanisms underlying both beneficial and undesirable opioid actions are poorly understood. Recently, the three currently known mammalian mitogen-activated protein kinase (MAPK) signaling cascades (extracellular signal-related kinase [ERK], stress-activated protein kinase, and p38 kinase) were shown to play important roles in transducing receptor-mediated signaling processes. METHODS To determine whether any of these kinase cascades were activated by opioids, mu… CONTINUE READING