Opioid control of MAP kinase cascade.

  title={Opioid control of MAP kinase cascade.},
  author={R{\"u}diger Schulz and Daniela A Eisinger and Andrea Wehmeyer},
  journal={European journal of pharmacology},
  volume={500 1-3},
Activation of G protein-coupled receptors (GPCRs) may result in phosphorylation of extracellular signal-regulated kinases 1/2 (ERK 1/2). The signaling pathway involves ectodomain shedding, generating epidermal growth factor (EGF)-like ligands, which in turn stimulate the mitogen-activated protein kinase (MAPK) via EGF receptors. The present study investigates into the control of MAPKs by opioidergic GPCRs in human embryonic kidney cells (HEK 293). Experiments were conducted with cells… CONTINUE READING


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