Opioid antagonists in broadly defined behavioral addictions: a narrative review

  title={Opioid antagonists in broadly defined behavioral addictions: a narrative review},
  author={Marcelo Piquet-Pess{\^o}a and L. Fontenelle},
  journal={Expert Opinion on Pharmacotherapy},
  pages={835 - 844}
  • Marcelo Piquet-Pessôa, L. Fontenelle
  • Published 2016
  • Medicine
  • Expert Opinion on Pharmacotherapy
  • ABSTRACT Introduction: Naltrexone (NTX), a mu-opioid receptor antagonist, has been approved for the treatment of alcoholism and opioid dependence. More recently, however, NTX and a related drug, nalmefene (NMF), have also shown positive results for the treatment of gambling disorders. Areas Covered: In this study, we reviewed the trials testing the effect of opioid antagonists (OA) in gambling disorders and in other broadly defined behavioral addictions, including selected DSM-5 disruptive… CONTINUE READING


    Publications referenced by this paper.
    Multicenter investigation of the opioid antagonist nalmefene in the treatment of pathological gambling.
    • 249
    • Highly Influential
    Opioid antagonists in the treatment of impulse-control disorders.
    • 127
    Opioid antagonists for alcohol dependence.
    • 371
    Treatment of compulsive sexual behaviour with naltrexone and serotonin reuptake inhibitors: two case studies.
    • 74
    • Highly Influential
    Treatment of Gambling Disorders
    • 42
    • PDF
    A double-blind, placebo-controlled study of the opiate antagonist naltrexone in the treatment of pathological gambling urges.
    • 155
    • Highly Influential
    Pharmacological treatments in pathological gambling
    • 63
    Neurocircuitry of Addiction
    • 2,325
    • PDF