Opioid antagonists and drinking: evidence of kappa-receptor involvement.


Diprenorphine, naloxone, MR-2266-BS and WIN-44,441-3 were compared for their ability to antagonize morphine analgesia and to decrease deprivation-induced drinking in rats. Diprenorphine and naloxone were markedly more potent (32x) than MR-2266-BS and WIN-44,441-3 in antagonizing the analgesic effects of morphine. In contrast, diprenorphine, naloxone and MR-2266-BS decreased deprivation-induced drinking over a similar dose range. The doses required to reduce fluid consumption were higher than those necessary to antagonize morphine. WIN-44,441-3 was ineffective in decreasing drinking. The relatively similar potencies of diprenorphine, naloxone and MR-2266-BS for decreasing deprivation-induced drinking suggest that the effect on drinking involves antagonist activity at a kappa-opioid receptor.


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@article{Leander1983OpioidAA, title={Opioid antagonists and drinking: evidence of kappa-receptor involvement.}, author={J. David Leander and Martin D. Hynes}, journal={European journal of pharmacology}, year={1983}, volume={87 4}, pages={481-4} }