Opioid and benzodiazepine contributions to etomidate-associated adrenal insufficiency

  title={Opioid and benzodiazepine contributions to etomidate-associated adrenal insufficiency},
  author={H. W. Daniell},
  journal={Intensive Care Medicine},
  • H. Daniell
  • Published 16 September 2008
  • Medicine, Biology
  • Intensive Care Medicine
Dear Editor, Both opioids and benzodiazepines independently and characteristically lower cortisol levels and may contribute to symptomatic adrenal insufficiency. The recent publications by Dr’s den Brinker et al. [1] and Vinclair et al. [2] add to the ongoing debate regarding the importance of inhibited cortisol production in determining the most appropriate use of etomidate. However, as in other related studies, the authors did not consider possible contributions by concurrently administered… 
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