• Corpus ID: 46259020

Opioid agonist and antagonist properties of diastereoisomeric N-tetrahydronoroxymorphones in mice.

@article{Ramabadran1985OpioidAA,
  title={Opioid agonist and antagonist properties of diastereoisomeric N-tetrahydronoroxymorphones in mice.},
  author={Krishnaswami Ramabadran and M F Jen},
  journal={Archives internationales de pharmacodynamie et de therapie},
  year={1985},
  volume={274 2},
  pages={
          180-8
        }
}
  • K. RamabadranM. Jen
  • Published 1 April 1985
  • Biology, Chemistry
  • Archives internationales de pharmacodynamie et de therapie
Opioid agonist and antagonist properties of diastereoisomeric N-Tetrahydrofurfurylnoroxymorphones, Mr 2096 and Mr 2097 were examined in mice using the hot plate and tail flick tests and on acute dependence. Subcutaneous administrations of Mr 2096, the agonist diastereoisomer and Mr 2097, the antagonist diastereoisomer respectively produced analgesia and hyperalgesia in these tests, confirming the involvement of stereoselective opioid receptors in the regulation of thermonociception…