Opioid agonist and antagonist behavioural effects of buprenorphine.

  title={Opioid agonist and antagonist behavioural effects of buprenorphine.},
  author={J. David Leander},
  journal={British journal of pharmacology},
  volume={78 4},
1 The agonist and antagonist effects of a range of buprenorphine doses (0.08-20 mg/kg) were studied on the responding of pigeons under a multiple fixed-ratio, fixed-interval schedule of grain presentation. Various doses (0.02-10 mg/kg) of buprenorphine were also tested in pigeons trained to discriminate between injections of 0.05 mg/kg of fentanyl and injections of distilled water. 2 Buprenorphine, over a broad dose range (0.08-5 mg/kg), increased the rates of responding in the fixed-interval… CONTINUE READING

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