Opioid Resistance Associated with CYP3A4 Hyperactivity and COMT Polymorphism in an Oncological Patient.

We describe an interesting case of opioid unresponsiveness, showing the importance of clinical history, integrated with pharmacokinetic and pharmacogenomic analysis, to shed light on mechanisms of abnormal response to opioid analgesics and provide clinicians with strategies to overcome opioid resistance. A 71-year-old woman (height 1.55 m, weight 48 kg) of… (More)