Opioid Receptors and Signaling on Cells from the Immune System

@article{Bidlack2006OpioidRA,
  title={Opioid Receptors and Signaling on Cells from the Immune System},
  author={Jean M Bidlack and Maxim Khimich and Amy L. Parkhill and Sarah Sumagin and Baoyong Sun and Christopher M Tipton},
  journal={Journal of Neuroimmune Pharmacology},
  year={2006},
  volume={1},
  pages={260-269}
}
This review discusses the criteria for determining whether a binding site or functional response is directly mediated by either the mu, delta, or kappa opioid receptors. In 1988, Sibinga and Goldstein published the first review that addressed whether cells from the immune system express opioid receptors. The criteria that they used, namely, structure–activity relationships, stereoselectivity, dose- and concentration-dependence, and saturability are still relevant criteria today for determining… CONTINUE READING

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