Opioid Receptor Blockade Improves Mesenteric Responsiveness in Biliary Cirrhosis

  title={Opioid Receptor Blockade Improves Mesenteric Responsiveness in Biliary Cirrhosis},
  author={Mohammad Reza Ebrahimkhani and Leila Moezi and Samira Kiani and Shahin Merat and Ahmad Reza Dehpour},
  journal={Digestive Diseases and Sciences},
Arterial vasodilation with concomitant hyperdynamic circulation is a common finding in cirrhotic subjects. Elevated levels of plasma endogenous opioid peptides have been reported in cholestasis and cirrhosis. Increased opioid peptides contribute to different manifestations of chronic liver disease such as pruritis, ascitis, and hepatic encephalopathy. In this study the potential role of opioid system in cirrhosis-induced vascular hyporesponsiveness was investigated. Bile duct ligated and sham… CONTINUE READING


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