Opioid Insights

@article{Fine2004OpioidI,
  title={Opioid Insights},
  author={Perry G. Fine},
  journal={Journal of Pain \& Palliative Care Pharmacotherapy},
  year={2004},
  volume={18},
  pages={75 - 79}
}
  • P. Fine
  • Published 1 January 2004
  • Medicine, Psychology, Biology
  • Journal of Pain & Palliative Care Pharmacotherapy
Opioid analgesics are an irreplaceable component of pharmacotherapy of numerous pain-producing conditions. Clinicians and patients must contend with the imperfect nature of this class of drugs, trying to balance benefits and burdens on a continual basis. New literature related to evidence-based selection of opioids and the neurobiological phenomenon of opioid induced hyperalgesia are reviewed. A matrix describing critical elements in the selection of opioid analgesics, both for initial therapy… 

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References

SHOWING 1-4 OF 4 REFERENCES

Withdrawal hyperalgesia after acute opioid physical dependence in nonaddicted humans: a preliminary study.

Side effect

A side effect occurs when a procedure or function changes the value of a global variable. This is one reason why the use of global variables is deplored in programming; they allow the possibility of