• DOI:10.1124/jpet.119.259242
Corpus ID: 196814087

Opioid-Induced Signaling and Antinociception Are Modulated by the Recently Deorphanized Receptor, GPR171

@article{McDermott2019OpioidInducedSA,
  title={Opioid-Induced Signaling and Antinociception Are Modulated by the Recently Deorphanized Receptor, GPR171},
  author={M. McDermott and Leela Afrose and I. Gomes and L. Devi and E. Bobeck},
  journal={The Journal of Pharmacology and Experimental Therapeutics},
  year={2019},
  volume={371},
  pages={56 - 62}
}

• M. McDermott, Leela Afrose, +2 authors E. Bobeck
• Published 2019
• Medicine
• The Journal of Pharmacology and Experimental Therapeutics

ProSAAS is one of the most widely expressed proteins throughout the brain and was recently found to be upregulated in chronic fibromyalgia patients. BigLEN is a neuropeptide that is derived from ProSAAS and was recently discovered to be the endogenous ligand for the orphan G protein-coupled receptor GPR171. Although BigLEN-GPR171 has been found to play a role in feeding and anxiety behaviors, it has not yet been explored in pain and opioid modulation. The purpose of this study was to evaluate… Expand

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