Opioid-Induced Signaling and Antinociception Are Modulated by the Recently Deorphanized Receptor, GPR171

@article{McDermott2019OpioidInducedSA,
  title={Opioid-Induced Signaling and Antinociception Are Modulated by the Recently Deorphanized Receptor, GPR171},
  author={M. McDermott and Leela Afrose and I. Gomes and L. Devi and E. Bobeck},
  journal={The Journal of Pharmacology and Experimental Therapeutics},
  year={2019},
  volume={371},
  pages={56 - 62}
}
ProSAAS is one of the most widely expressed proteins throughout the brain and was recently found to be upregulated in chronic fibromyalgia patients. BigLEN is a neuropeptide that is derived from ProSAAS and was recently discovered to be the endogenous ligand for the orphan G protein-coupled receptor GPR171. Although BigLEN-GPR171 has been found to play a role in feeding and anxiety behaviors, it has not yet been explored in pain and opioid modulation. The purpose of this study was to evaluate… Expand
1 Citations
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