Opioid-Induced Hyperalgesia in the Nonsurgical Setting: A Systematic Review

@article{Yang2019OpioidInducedHI,
  title={Opioid-Induced Hyperalgesia in the Nonsurgical Setting: A Systematic Review},
  author={David Z Yang and Billy Sin and Joshua Beckhusen and Dawei Xia and Rebecca Khaimova and Ilia Iliev},
  journal={American Journal of Therapeutics},
  year={2019},
  volume={26},
  pages={e397–e405}
}
Background: Opioid-induced hyperalgesia (OIH) is a phenomenon that causes an increased pain sensitization and perception of pain to noxious stimuli secondary to opioid exposure. [] Key Method This review included randomized controlled trials with objectives to identify OIH in the nonsurgical setting. The clinical outcomes of interest were identification of OIH, adverse events, and impact of OIH on opioid consumption. Results: The search identified 8 studies that fulfilled the criteria.
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Findings suggested that the RIH was initiated by decreased GABA release, and KCC2 enhancer was proved to potentiate antinociceptive effect of GABAAR agonist in RIH.
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