Opioid-Induced Hyperalgesia in the Nonsurgical Setting: A Systematic Review.


BACKGROUND Opioid-induced hyperalgesia (OIH) is a phenomenon that causes an increased pain sensitization and perception of pain to noxious stimuli secondary to opioid exposure. While this clinical effect has been described in the surgical setting, it is unclear if OIH occurs in the nonsurgical setting. STUDY QUESTION To review the available literature… (More)
DOI: 10.1097/MJT.0000000000000734


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