Opinion: A call for an independent inquiry into the origin of the SARS-CoV-2 virus

  title={Opinion: A call for an independent inquiry into the origin of the SARS-CoV-2 virus},
  author={Neil L Harrison and Jeffrey D. Sachs},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  • N. HarrisonJ. Sachs
  • Published 19 May 2022
  • Medicine
  • Proceedings of the National Academy of Sciences of the United States of America

SARS-CoV-2 furin cleavage site was not engineered

  • R. Garry
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2022
It is suggested that the UNC and WIV coronavirologists may have mimicked human ENaC FCS to make SARSCoV-2 more infectious for lung epithelia, but numerous features of SARS-CoV- 2 FCS demonstrate that it was not engineered to mimic human EnaC.

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Forensic Analysis of Novel SARS2r-CoV Identified in Game Animal Datasets in China Shows Evolutionary Relationship to Pangolin GX CoV Clade and Apparent Genetic Experimentation

It is found that NGS datasets containing the novel SARS2r-CoV are contaminated with significant Homo sapiens genetic material, and numerous viruses not associated with the host animals sampled.



High-resolution epitope mapping and characterization of SARS-CoV-2 antibodies in large cohorts of subjects with COVID-19

The evolution of SARS-CoV-2 mutants towards reduced antibody response highlight the importance of data-driven development of the vaccines and therapies to treat COVID-19.

OUP accepted manuscript

  • Molecular Biology And Evolution
  • 2021

Recovery of Deleted Deep Sequencing Data Sheds More Light on the Early Wuhan SARS-CoV-2 Epidemic

Phylogenetic analysis of deleted SARS-CoV-2 sequences in the context of carefully annotated existing data suggests that the Huanan Seafood Market sequences that are the focus of the joint WHO-China report are not fully representative of the viruses in Wuhan early in the epidemic.

The furin cleavage site in the SARS-CoV-2 spike protein is required for transmission in ferrets.

It is found that the selective advantage of SARS-CoV-2 in lung and primary human airway epithelial cells depends on the expression of the cell surface protease TMPRSS2, which enables endosome-independent virus entry by a route that avoids antiviral IFITM proteins.

Opinion: To stop the next pandemic, we need to unravel the origins of COVID-19

  • D. Relman
  • Biology
    Proceedings of the National Academy of Sciences
  • 2020
To avoid or mitigate the dire consequences of this and future pandemics, unraveling the origins of SARS-CoV-2 and COVID-19 will be essential—even though a definitive answer may be elusive, and an objective analysis means broaching some uncomfortable possibilities.

A Pathophysiological Model for COVID-19: Critical Importance of Transepithelial Sodium Transport upon Airway Infection

A pathophysiological model is proposed that defines the possible role of apical sodium transport mediated by the epithelial sodium channel (ENaC) during the early phases of the infection in the airways and how it triggers innate and native immunity.

A palindromic RNA sequence as a common breakpoint contributor to copy-choice recombination in SARS-COV-2

This paper demonstrates by bioinformatic analysis that such recombinational events are facilitated by short oligonucleotide “breakpoint sequences”, similar to CAGAC, that direct recombination naturally to certain positions in the genome at the boundaries between blocks of RNA code and potentially RNA structure, providing a natural explanation for the biogenesis of SARS-CoV-2 over time and in the wild.