Opiates inhibit acetylcholine release from Torpedo nerve terminals by blocking Ca2+ influx.

@article{Michaelson1984OpiatesIA,
  title={Opiates inhibit acetylcholine release from Torpedo nerve terminals by blocking Ca2+ influx.},
  author={Daniel M. Michaelson and G McDowall and Yosef Sarne},
  journal={Journal of neurochemistry},
  year={1984},
  volume={43 3},
  pages={614-8}
}
In the present communication we report that Ca2+-dependent acetylcholine release from K+-depolarized Torpedo electric organ synaptosomes is inhibited by morphine, and that this effect is blocked by the opiate antagonist naloxone. This finding suggests that the purely cholinergic Torpedo electric organ neurons contain presynaptic opiate receptors whose activation inhibits acetylcholine release. The mechanisms underlying this opiate inhibition were investigated by comparing the effects of… CONTINUE READING