Opiates, mast cells and histamine release.

@article{Barke1993OpiatesMC,
  title={Opiates, mast cells and histamine release.},
  author={K E Barke and Lindsay B. Hough},
  journal={Life sciences},
  year={1993},
  volume={53 18},
  pages={
          1391-9
        }
}
Opiates have long been known to cause the release of histamine from mast cells, resulting in several undesirable effects, such as hypotension, urticaria, pruritus, and tachycardia. The mechanism of this opiate response has remained unclear, although it is known to be non-immunological in nature. A survey of the histamine-releasing properties of a variety of opiates shows that the pharmacology of opiate-induced histamine release from mast cells is distinct from that of known opiate receptors… CONTINUE READING
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