Opiate vs non-opiate footshock-induced analgesia (FSIA): the body region shocked is a critical factor.

@article{Watkins1982OpiateVN,
  title={Opiate vs non-opiate footshock-induced analgesia (FSIA): the body region shocked is a critical factor.},
  author={Linda R. Watkins and D A Cobelli and Patricia L. Faris and Mario D. G. Aceto and Dr. Jaques Mayer},
  journal={Brain research},
  year={1982},
  volume={242 2},
  pages={299-308}
}
Previous work has demonstrated that footshock can elicit either opiate or non-opiate analgesia. The present study has demonstrated that one critical factor determining the involvement of endogenous opioids is the body region shocked. Using 90 s shock, front paw shock produced an opiate analgesia which was significantly antagonized by as little as 0.1 mg/kg systemic naloxone and morphine tolerance. In the latter experiment, a parallel recovery of the analgesic potencies of both front paw shock… CONTINUE READING