Opiate self-administration as a measure of chronic nociceptive pain in arthritic rats

@article{Colpaert2001OpiateSA,
  title={Opiate self-administration as a measure of chronic nociceptive pain in arthritic rats},
  author={F. C. Colpaert and Jean-P. Tarayre and M Alliaga and Liesbeth A. Bruins Slot and Nadine Attal and Wouter Koek},
  journal={Pain},
  year={2001},
  volume={91},
  pages={33-45}
}
&NA; The study examined the validity of oral fentanyl self‐administration (FSA) as a measure of the chronic nociceptive pain that develops in rats with adjuvant arthritis independently of acute noxious challenges. Arthritic rats self‐administered more of a 0.008 mg/ml fentanyl solution (up to 3.4 g/rat per day) than non‐arthritic controls (0.5 g/rat per day) and did so with a biphasic time course that reached peak during weeks 3 and 4 after inoculation with Mycobacterium butyricum. The time… Expand
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