Opiate reward: sites and substrates.

@article{Wise1989OpiateRS,
  title={Opiate reward: sites and substrates.},
  author={R A Wise},
  journal={Neuroscience and biobehavioral reviews},
  year={1989},
  volume={13 2-3},
  pages={129-33}
}
  • R A Wise
  • Published 1989 in Neuroscience and biobehavioral reviews
Opiates appear to have rewarding actions at more than one locus in the brain. Studies of the effects of dopaminergic lesions and dopamine receptor blockade indicate that intravenous heroin self-administration depends importantly on a dopaminergic substrate. Mapping of effective injection sites for morphine-conditioned place preference establishes one site of rewarding action near the dopamine cell bodies of the ventral tegmental area (VTA). Studies of the complex interactions of opiates… CONTINUE READING

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