Opiate receptors--the historical breakthrough in drug research.

  title={Opiate receptors--the historical breakthrough in drug research.},
  author={Lars Terenius},
  journal={Biochemical Society symposium},
Morphine (Fig. 1) remains the most powerful analgesic but its therapeutic value is compromised by its strong reinforcing properties, making it highly addictive. This has stimulated the quest to find an analgesic lacking dependence-producing properties. So far no such drug has been discovered. However, this search has helped to disclose the large range of endogenous opioid peptides and the various receptors on which they act. This diversity and opportunity for interaction between exogenous drug… CONTINUE READING

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