Opiate receptor subtype binding in gerbil hippocampus is altered by forebrain ischemia.

@article{Miller1989OpiateRS,
  title={Opiate receptor subtype binding in gerbil hippocampus is altered by forebrain ischemia.},
  author={Leonard P. Miller and David C. Perry},
  journal={Brain research},
  year={1989},
  volume={495 2},
  pages={367-72}
}
A role for endogenous opioids in trauma-induced brain injury has been supported by pharmacological studies. The present series of experiments were initiated to extend these observations by measuring opiate receptor subtype binding in gerbil hippocampus following 7 days recovery from a 10 min ischemic insult. Quantitative in vitro autoradiography was utilized to measure mu [( 3H]DAGO), kappa [( 3H]bremazocine + 10 microM morphiceptin + 100 nM DSLET), delta [( 3H]DSLET + 10 microM morphiceptin… CONTINUE READING