Opiate properties of SKF 525A.

  title={Opiate properties of SKF 525A.},
  author={Tracy Kwei-Liang Ho and Frank S. Labella and Carl Pinsky},
  journal={Canadian journal of physiology and pharmacology},
  volume={56 4},
SKF 525A, a classical inhibitor of microsomal drug-metabolizing enzymes, is structurally similar to the diphenylpropylamine analgesics, and certain reported effects in animals resemble those produced by opiate drugs. In an opiate radioreceptor assay, SKF 525A was 50 times less potent than methadone in the absence of sodium and 10 times less potent in the prescence of sodium. The nature of the sodium effect indicates SKF 525A to have less opiate agonist character than does methadone. In mice, 2… CONTINUE READING

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