Opiate mixed agonist-antagonist interactions with histamine antagonists vs. morphine.

@article{Hui1985OpiateMA,
  title={Opiate mixed agonist-antagonist interactions with histamine antagonists vs. morphine.},
  author={F W Hui and Chung Leung Sun and Joseph Hanig},
  journal={Neurobehavioral toxicology and teratology},
  year={1985},
  volume={7 5},
  pages={443-7}
}
Anecdotal reports of polydrug abuse in humans using tripelennamine and pentazocine prompted our investigation of drug interactions between tripelennamine, morphine and various synthetic mixed agonist-antagonists in mice. Pentazocine, nalbuphene and butorphanol, at doses of 4.0-8.0 mg/kg, all showed frank or borderline intrinsic antinociceptive activity and potentiated the tripelennamine response, whereas cyclazocine, an experimental compound with very strong mixed agonist-antagonist qualities… CONTINUE READING