• Chemistry, Geology, Medicine
  • Published in
    The Journal of clinical…
    1996
  • DOI:10.1172/JCI118530

Opiate-mediated inhibition of calcium signaling is decreased in dorsal root ganglion neurons from the diabetic BB/W rat.

@article{Hall1996OpiatemediatedIO,
  title={Opiate-mediated inhibition of calcium signaling is decreased in dorsal root ganglion neurons from the diabetic BB/W rat.},
  author={Karen E. Hall and A A Sima and John W. Wiley},
  journal={The Journal of clinical investigation},
  year={1996},
  volume={97 5},
  pages={
          1165-72
        }
}
The effect of diabetes mellitus on opiate-mediated inhibition of calcium current density (I(D Ca) [pA pF-1]) and cytosolic calcium response ([Ca2+]i nM) to depolarization with elevated KCl and capsaicin was assessed. Experiments were performed on isolated, acutely dissociated dorsal root ganglion (DRG) neurons from diabetic, BioBreeding/Worcester (BB/W) rats and age-matched control animals. Sciatic nerve conduction velocity was significantly decreased in diabetic animals compared to controls… CONTINUE READING

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Taurine replacement attenuates hyperalgesia and abnormal calcium signaling in sensory neurons of STZ-D rats.

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