Opiate-induced inhibition of the visceral distension reflex by peripheral and central mechanisms

@article{Clark1985OpiateinducedIO,
  title={Opiate-induced inhibition of the visceral distension reflex by peripheral and central mechanisms},
  author={Susan J Clark and Thomas W. Smith},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1985},
  volume={330},
  pages={179-183}
}
1. Distension of the proximal ileum by elevation of the intraluminal pressure, caused a transient, reflex fall in blood pressure of urethane-anaesthetised rats. The threshold intraluminal pressure required to evoke a reflex response was increased by codeine, but not by the quaternary opiate agonist N-methylmorphine. 2. The magnitude of the reflex… CONTINUE READING