Opiate-induced inhibition of the visceral distension reflex by peripheral and central mechanisms

@article{Clark2004OpiateinducedIO,
  title={Opiate-induced inhibition of the visceral distension reflex by peripheral and central mechanisms},
  author={S. J. Clark and T. W. Smith},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2004},
  volume={330},
  pages={179-183}
}
Summary1.Distension of the proximal ileum by elevation of the intraluminal pressure, caused a transient, reflex fall in blood pressure of urethane-anaesthetised rats. The threshold intraluminal pressure required to evoke a reflex response was increased by codeine, but not by the quaternary opiate agonist N-methylmorphine.2.The magnitude of the reflex hypotension was decreased by codeine, morphine and N-methylmorphine. The quaternary opiate antagonist N-methylnalorphine reduced the effects of N… Expand
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