Opiate-induced adenylyl cyclase superactivation is isozyme-specific.

  title={Opiate-induced adenylyl cyclase superactivation is isozyme-specific.},
  author={Tomer Avidor-Reiss and Igal Nevo and Daniella Saya and Michael Bayewitch and Zvi Vogel},
  journal={The Journal of biological chemistry},
  volume={272 8},
While acute activation of inhibitory Gi/o-coupled receptors leads to inhibition of adenylyl cyclase, chronic activation of such receptors leads to an increase in cAMP accumulation. This phenomenon, observed in many cell types, has been referred to as adenylyl cyclase superactivation. At this stage, the mechanism leading to adenylyl cyclase superactivation and the nature of the isozyme(s) responsible for this phenomenon are largely unknown. Here we show that transfection of adenylyl cyclase… CONTINUE READING
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