Opiate and alpha 1-adrenergic receptors in mice responding to morphine with sedation or with running fit.

@article{Michaluk1991OpiateAA,
  title={Opiate and alpha 1-adrenergic receptors in mice responding to morphine with sedation or with running fit.},
  author={Jerzy Michaluk and Lucyna Antkiewicz-Michaluk and A Rokosz-Pelc and Jerzy Vetulani},
  journal={Polish journal of pharmacology and pharmacy},
  year={1991},
  volume={43 2},
  pages={115-9}
}
Two subpopulations of Albino Swiss mice were selected on the basis of their response to a dose of 20 mg/kg ip of morphine: individuals in which the drug constantly produced sedation, and those which responded with running fit. Both subpopulations of mice had cerebral opiate delta and mu receptors (defined as [3H]DADLE and [3H]naloxone binding sites) of similar Bmax and KD values but mice responding with sedation showed lower density of alpha 1-adrenoceptors (defined as [3H]prazosin binding… CONTINUE READING

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