Opiate Receptor: Demonstration in Nervous Tissue

  title={Opiate Receptor: Demonstration in Nervous Tissue},
  author={C. Pert and S. Snyder},
  pages={1011 - 1014}
Tritiated naloxone, a powerful opiate antagonist, specifically binds to an opiate receptor of mammalian brain and guinea pig intestine. Competition for the opiate receptor by various opiates and their antagonists closely parallels their pharmacological potency. The opiate receptor is confined to nervous tissue. 
Opiate Receptors
Abstract Binding of radioactive opiates and opiate antagonists to the opiate receptor in the brain and other tissues can be shown. This binding mediates the pharmacologic effects of the drugs. The ...
Opiate receptor heterogeneity in human brain regions
Abstract Heterogeneity of opiate receptors has been demonstrated in human brain regions by cross-competition between naloxone and D -Ala 2 , D -Leu 5 -enkephalin for receptor binding. TheExpand
Regional Distribution of Opiate Receptor Binding in Monkey and Human Brain
The authors describe a relationship between the distribution of opiate receptors and of neurotransmitters that varies dramatically throughout the human and monkey brain. Expand
Multiple opiate receptors
Whether the complex effects of opioid peptides are mediated by single or multiple types of opiate receptors is discussed. Expand
Failure of ketamine to interact with opiate receptors.
Ketamine, an anesthetic agent endowed with several morphine-like effects, failed to displace 3H-dihydromorphine or 3H-methionine-enkephalin from opiate receptors in the rat brainExpand
Opiate Agonists and Antagonists Discriminated by Receptor Binding in Brain
Sodium enhances antagonist binding in vitro but decreases agonist binding, a qualitative difference that may be relevant to the divergent pharmacological properties of opiate agonists and antagonists. Expand
Neurotransmitter activity in the brain: Focus on the opiate receptor
AbstractUnderstanding the molecular basis of synaptic transmission requires a biochemical approach to the receptors upon which neurotransmitters act. Binding studies with radioactiveExpand
Opiate receptor in normal and drug altered brain function*
The isolation of a morphine-like peptide which may be a central nervous system neurotransmitter sheds light on normal brain mechanisms regulating pain and emotion. Expand
Endogenous opioid peptides: multiple agonists and receptors
It is concluded that the opioid peptidergic system has agonists of different characteristics which interact with more than one type of receptor. Expand
Cellular site of opiate dependence
It is shown that opiate dependence and associated tolerance develop within neurones bearing specific opiate receptors (opiate-sensitive neurones) within the cyclic AMP system in response to inhibition by opiate of a neuronal adenylate cyclase. Expand


Stereospecific and nonspecific interactions of the morphine congener levorphanol in subcellular fractions of mouse brain.
In mouse brain the stereospecific binding of levorphanol represents only 2% of the total association of drug with tissue, and it was found only in certain membrane fractions. Expand
Dopamine (3-hydroxytyramine) and brain function.
A good case can be made for the concept that the physiological activity of the brain dopamine is quite different from that of brain norepinephrine, although there are as yet no experiments to positively show that dopamine is a true neuro-transmitter substance in the brain. Expand
Gas chromatographic evaluation of the influence of oxotremorine upon the regional distribution of acetylcholine in rat brain 1
The results obtained by application of this specific gas chromatographic method to the investigation of acetylcholine content in discrete brain regions and the alteration of its distribution following administration of oxotremorine are presented. Expand
Comparative potencies of codeine and its demethylated metabolites after intraventricular injection in the mouse.
  • T. K. Adler
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
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The technique of direct intraventricular injection in the conscious mouse was used to study the pharmacologic effects of codeine, morphine, and norcodeine, respectively. It was found that theExpand
The use of microwave radiation in the determination of acetylcholine in the rat brain.
It was concluded that sacrificing rats by microwave irradiation, coupled with pyrolysis-gas chromatographic analysis of ACh, permitted a more accurate and convenient determination of in vivo levels of A Ch in brain areas. Expand
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Stereochemical factors and receptor interactions associated with narcotic analgesics.
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