Opiate Modulation of Striatal Dopamine and Hippocampal Norepinephrine Release Following Morphine Withdrawal

@article{Grasing1997OpiateMO,
  title={Opiate Modulation of Striatal Dopamine and Hippocampal Norepinephrine Release Following Morphine Withdrawal},
  author={Kenneth A. Grasing and Daniel A. Bills and Suchandra Ghosh and Stephan D. Schlussman and Amrish Patel and John J Woodward},
  journal={Neurochemical Research},
  year={1997},
  volume={22},
  pages={239-248}
}
When opiates are abruptly withdrawn after chronic treatment, increases in hippocampal noradre-nergic function are observed which are accompanied by decreases in striatal dopamine release. The latter effects have to shown to persist for several weeks following the onset of opiate withdrawal. We examined the long-term effects of opiate withdrawal on 4-aminopyridine and potassium stimulated release of striatal dopamine and hippocampal norepinephrine. Tissue samples were obtained either from rats… CONTINUE READING