Ophthalmologic and systemic manifestations of Alström's disease.

  title={Ophthalmologic and systemic manifestations of Alstr{\"o}m's disease.},
  author={R H Millay and Richard G. Weleber and John R. Heckenlively},
  journal={American journal of ophthalmology},
  volume={102 4},
Alström's syndrome consists of pigmentary retinopathy, diabetes, obesity, normal mental capacity, and sensorineural deafness. The early retinal findings are optic atrophy, salt-and-pepper pigment epithelial abnormalities, and marked vascular attenuation. Later in the disease process, diffuse areas of chorioretinal atrophy and large clumps of pigment develop. Severe visual loss in the first decade is characteristic and is an important point in the differential diagnosis. Clinically evident renal… CONTINUE READING
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