Ophiobolins from the Mangrove Fungus Aspergillus ustus.

  title={Ophiobolins from the Mangrove Fungus Aspergillus ustus.},
  author={Tonghan Zhu and Zhenyu Lu and Jie Fan and Liping Wang and Guoliang Zhu and Yi Wang and Xia Li and Kui Hong and Pawinee Piyachaturawat and Arthit Chairoungdua and Weiming Zhu},
  journal={Journal of natural products},
  volume={81 1},
Seven new ophiobolins (1-5, 12, and 14) along with the 11 known analogues (6-11, 13, 15-18) were isolated from the ethyl acetate extracts of the liquid and solid cultures of the mangrove fungus Aspergillus ustus 094102. The structures including the absolute configurations of the seven new compounds were elucidated by spectroscopic analysis, chemical methods, and quantum ECD calculations. Compounds 4-8 and 11-15 showed cytotoxicities against the G3K, MCF-7, MD-MBA-231, MCF/Adr, A549, and HL-60… CONTINUE READING