Operationalizing hippocampal volume as an enrichment biomarker for amnestic mild cognitive impairment trials: effect of algorithm, test-retest variability, and cut point on trial cost, duration, and sample size.

Abstract

The objective of this study was to evaluate the effect of computational algorithm, measurement variability, and cut point on hippocampal volume (HCV)-based patient selection for clinical trials in mild cognitive impairment (MCI). We used normal control and amnestic MCI subjects from the Alzheimer's Disease Neuroimaging Initiative 1 (ADNI-1) as normative… (More)
DOI: 10.1016/j.neurobiolaging.2013.09.039

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Cite this paper

@article{Yu2014OperationalizingHV, title={Operationalizing hippocampal volume as an enrichment biomarker for amnestic mild cognitive impairment trials: effect of algorithm, test-retest variability, and cut point on trial cost, duration, and sample size.}, author={Peng Yu and Jia Sun and Robin Wolz and Diane Stephenson and James Brewer and Nick C. Fox and Patricia E. Cole and Clifford R. Jack and Derek L. G. Hill and Adam J. Schwarz}, journal={Neurobiology of aging}, year={2014}, volume={35 4}, pages={808-18} }