Operational strategies, monitoring and control of heterologous protein production in the methylotrophic yeast Pichia pastoris under different promoters: A review

@article{Cs2006OperationalSM,
  title={Operational strategies, monitoring and control of heterologous protein production in the methylotrophic yeast Pichia pastoris under different promoters: A review},
  author={Oriol C{\'o}s and Ram{\'o}n Coscoll{\'a} Ram{\'o}n and Jos{\'e} Luis Gonz{\'a}lez Montesinos and Francisco Valero},
  journal={Microbial Cell Factories},
  year={2006},
  volume={5},
  pages={17 - 17}
}
The methylotrophic yeast Pichia pastoris has been widely reported as a suitable expression system for heterologous protein production. The use of different phenotypes under PAOX promoter, other alternative promoters, culture medium, and operational strategies with the objective to maximize either yield or productivity of the heterologous protein, but also to obtain a repetitive product batch to batch to get a robust process for the final industrial application have been reported. Medium… CONTINUE READING
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