Operation of the voltage sensor of a human voltage- and Ca2+-activated K+ channel.

  title={Operation of the voltage sensor of a human voltage- and Ca2+-activated K+ channel.},
  author={Antonios Pantazis and Vadym Gudzenko and Nicoletta Savalli and Daniel C. Sigg and Riccardo Olcese},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={107 9},
Voltage sensor domains (VSDs) are structurally and functionally conserved protein modules that consist of four transmembrane segments (S1-S4) and confer voltage sensitivity to many ion channels. Depolarization is sensed by VSD-charged residues residing in the membrane field, inducing VSD activation that facilitates channel gating. S4 is typically thought to be the principal functional component of the VSD because it carries, in most channels, a large portion of the VSD gating charge. The VSDs… CONTINUE READING

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