Operant responding for sucrose by rats bred for high or low saccharin consumption.

  title={Operant responding for sucrose by rats bred for high or low saccharin consumption.},
  author={Blake A Gosnell and Anaya Mitra and Ross A. Avant and Justin J Anker and Marilyn Carroll and Allen Stuart Levine},
  journal={Physiology & behavior},
  volume={99 4},
The use of rats differing in the intake of sweet substances has highlighted some interesting parallels between taste preferences and drug self-administration. For example, rats selectively bred to consume high (HiS) or low (LoS) amounts of a 0.1% saccharin solution (when compared to water consumption), show corresponding differences across several measures of cocaine self-administration (HiS>LoS). In this study, we measured whether the two strains also differ when response requirements are… CONTINUE READING

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