Operant Self-Stimulation of Dopamine Neurons in the Substantia Nigra

  title={Operant Self-Stimulation of Dopamine Neurons in the Substantia Nigra},
  author={Mark A. Rossi and Tatyana Sukharnikova and Volodya Y. Hayrapetyan and Lucie Yang and Henry H. Yin},
  booktitle={PloS one},
We examined the contribution of the nigrostriatal DA system to instrumental learning and behavior using optogenetics in awake, behaving mice. Using Cre-inducible channelrhodopsin-2 (ChR2) in mice expressing Cre recombinase driven by the tyrosine hydroxylase promoter (Th-Cre), we tested whether selective stimulation of DA neurons in the substantia nigra pars compacta (SNC), in the absence of any natural rewards, was sufficient to promote instrumental learning in naive mice. Mice expressing ChR2… CONTINUE READING
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