Opening the flood-gates: how neutrophil-endothelial interactions regulate permeability.

  title={Opening the flood-gates: how neutrophil-endothelial interactions regulate permeability.},
  author={Matthew R Distasi and Klaus Ley},
  journal={Trends in immunology},
  volume={30 11},
Many diseases have an inflammatory component, where neutrophil interactions with the vascular endothelium lead to barrier dysfunction and increased permeability. Neutrophils increase permeability through secreted products such as the chemokines CXCL1, 2, 3, and 8, through adhesion-dependent processes involving beta(2) integrins interacting with endothelial ICAM-1, and through combinations where beta(2) integrin engagement leads to degranulation and secretion of heparin-binding protein. Some… CONTINUE READING
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