Opening the adaptive toolbox.


This is a discussion of the following three papers appearing in this special issue on adaptive designs: 'A regulatory view on adaptive/flexible clinical trial design' by H. M. James Hung, Robert T. O'Neill, Sue-Jane Wang and John Lawrence; 'Confirmatory clinical trials with an adaptive design' by Armin Koch; and 'FDA's critical path initiative: A… (More)


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@article{Wittes2006OpeningTA, title={Opening the adaptive toolbox.}, author={Janet T Wittes and Peter Anthony Lachenbruch}, journal={Biometrical journal. Biometrische Zeitschrift}, year={2006}, volume={48 4}, pages={598-603; discussion 613-22} }