Opening of voltage dependent anion channels promotes reactive oxygen species generation, mitochondrial dysfunction and cell death in cancer cells.

Abstract

Enhancement of aerobic glycolysis and suppression of mitochondrial metabolism characterize the pro-proliferative Warburg phenotype of cancer cells. High free tubulin in cancer cells closes voltage dependent anion channels (VDAC) to decrease mitochondrial membrane potential (ΔΨ), an effect antagonized by erastin, the canonical promotor of ferroptosis… (More)
DOI: 10.1016/j.bcp.2017.12.022

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Cite this paper

@article{DeHart2017OpeningOV, title={Opening of voltage dependent anion channels promotes reactive oxygen species generation, mitochondrial dysfunction and cell death in cancer cells.}, author={David N DeHart and Diana Fang and Kareem Heslop and Li Li and John J. Lemasters and Eduardo N. Maldonado}, journal={Biochemical pharmacology}, year={2017}, volume={148}, pages={155-162} }