Opening of the blood-brain barrier tight junction due to shock wave induced bubble collapse: a molecular dynamics simulation study.

@article{Goliaei2015OpeningOT,
  title={Opening of the blood-brain barrier tight junction due to shock wave induced bubble collapse: a molecular dynamics simulation study.},
  author={Ardeshir Goliaei and Upendra Adhikari and Max L. Berkowitz},
  journal={ACS chemical neuroscience},
  year={2015},
  volume={6 8},
  pages={1296-301}
}
Passage of a shock wave across living organisms may produce bubbles in the blood vessels and capillaries. It was suggested that collapse of these bubbles imposed by an impinging shock wave can be responsible for the damage or even destruction of the blood-brain barrier. To check this possibility, we performed molecular dynamics computer simulations on systems that contained a model of tight junction from the blood-brain barrier. In our model, we represent the tight junction by two pairs of… CONTINUE READING

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