Opening of potassium channels: the common cardioprotective link between preconditioning and natural hibernation?

@article{Kvelaitis1999OpeningOP,
  title={Opening of potassium channels: the common cardioprotective link between preconditioning and natural hibernation?},
  author={Egidijus Kėvelaitis and Jacqueline Peynet and Christian Mouas and Jean Marie Launay and Philippe Menasch{\'e}},
  journal={Circulation},
  year={1999},
  volume={99 23},
  pages={3079-85}
}
BACKGROUND The tolerance of hibernating mammals to cold hypoxia is related to a factor similar to agonists of delta-opioid receptors. This study was designed to assess whether activation of these receptors could reproduce the protection conferred by ischemic preconditioning and whether such cardioprotection was similarly mediated by an opening of ATP-sensitive potassium (KATP) channels. METHODS AND RESULTS Thirty-two isolated rat hearts were arrested with and stored in Celsior at 4 degrees C… CONTINUE READING

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  • JR Kersten, TJ Schmeling, DA Hettrick, PS Pagel, GJ Gross, DC. Warltier
  • Kevelaitis et al June
  • 1999

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