Opening of mitochondrial KATP channels enhances cardioprotection through the modulation of mitochondrial matrix volume, calcium accumulation, and respiration.

@article{Rousou2004OpeningOM,
  title={Opening of mitochondrial KATP channels enhances cardioprotection through the modulation of mitochondrial matrix volume, calcium accumulation, and respiration.},
  author={Anthony J. Rousou and Maria Ericsson and Micheline Federman and Sidney Levitsky and James D. McCully},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2004},
  volume={287 5},
  pages={
          H1967-76
        }
}
Previously, we have shown that the pharmacological opening of the mitochondrial ATP-sensitive K channels with diazoxide (DZX) enhances the cardioprotection afforded by magnesium-supplemented potassium (K/Mg) cardioplegia. To determine the mechanisms involved in the cardioprotection afforded by K/Mg + DZX cardioplegia, rabbit hearts (n=24) were subjected to isolated Langendorff perfusion. Control hearts were perfused for 75 min. Global ischemia (GI) hearts were subjected to 30 min of equilibrium… 

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