Opening of K(ATP) channels is mandatory for acquisition of ischemic tolerance by adenosine.

@article{Reshef2000OpeningOK,
  title={Opening of K(ATP) channels is mandatory for acquisition of ischemic tolerance by adenosine.},
  author={Ariell Reshef and O. K. Sperling and Esther Zoref-Shani},
  journal={Neuroreport},
  year={2000},
  volume={11 3},
  pages={463-5}
}
Binding of adenosine to neuronal adenosine receptors activates a signal transduction pathway (the adenosine mechanism), leading to a temporary ischemic tolerance. We have demonstrated before that induction of this mechanism in primary rat neuronal cultures, by activation of adenosine receptors, or by activation of protein kinase C (PKC), confers a wide time window of ischemic tolerance, lasting up to 72h, the early (immediate) part of which depends on opening of K(ATP) channels (glibenclamide… CONTINUE READING

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