Opening and closing motions in the periplasmic vitamin B12 binding protein BtuF.

@article{Kandt2006OpeningAC,
  title={Opening and closing motions in the periplasmic vitamin B12 binding protein BtuF.},
  author={Christian Kandt and Zhitao Xu and D. Peter Tieleman},
  journal={Biochemistry},
  year={2006},
  volume={45 44},
  pages={13284-92}
}
BtuF is the periplasmic binding protein (PBP) in the vitamin B(12) uptake system in Escherichia coli where it is associated with the ABC transporter BtuCD. When the ligand binds, PBPs generally display large conformational changes, commonly termed the Venus flytrap mechanism. BtuF belongs to a group of PBPs that, on the basis of crystal structures, does not appear to display such behavior. Using 480 ns multicopy molecular dynamics simulations of apo and holo forms of the protein, we investigate… CONTINUE READING

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