Opening–closing dynamics of the mitochondrial transcription pre-initiation complex

  title={Opening–closing dynamics of the mitochondrial transcription pre-initiation complex},
  author={Hajin Kim and G Tang and Smita Shukla Patel and Taekjip Ha},
  booktitle={Nucleic acids research},
Promoter recognition and local melting of DNA are key steps of transcription initiation catalyzed by RNA polymerase and initiation factors. From single molecule fluorescence resonance energy transfer studies of the yeast (Saccharomyces cerevisiae) mitochondrial RNA polymerase Rpo41 and its transcription factor Mtf1, we show that the pre-initiation complex is highly dynamic and undergoes repetitive opening-closing transitions that are modulated by Mtf1 and ATP. We found that Rpo41 alone has the… CONTINUE READING

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