Open trial of flutamide for treatment of obsessive-compulsive disorder.

@article{Altemus1999OpenTO,
  title={Open trial of flutamide for treatment of obsessive-compulsive disorder.},
  author={Margaret Altemus and Benjamin D. Greenberg and David J Keuler and Karen R Jacobson and Dennis L. Murphy},
  journal={The Journal of clinical psychiatry},
  year={1999},
  volume={60 7},
  pages={442-5}
}
BACKGROUND Several lines of evidence suggest that gonadal steroid hormones play a role in the onset and exacerbation of obsessive-compulsive disorder (OCD). In this study, we examined the effects of treatment with flutamide, a synthetic, nonsteroidal, competitive antagonist of the androgen receptor, on OCD symptoms. METHOD Eight outpatients meeting DSM-III-R criteria for OCD participated in an 8-week open trial of flutamide. The dose was increased from 250 mg/day to 750 mg/day over the first… CONTINUE READING