Open-source genomic analysis of Shiga-toxin-producing E. coli O104:H4.

  title={Open-source genomic analysis of Shiga-toxin-producing E. coli O104:H4.},
  author={H. G. E. Rohde and Junjie Jia Guowei Qin and Yujun Cui and Dongfang Li and Nicholas J. Loman and Moritz Hentschke and Wentong Chen and Fei Pu and Yangqing Peng and Junhua Li and Feng Xi and Shenghui Li and Yin Ping Li and Zhaoxi Zhang and Xianwei Yang and Meiru Zhao and Peng Wang and Yuanlin Guan and Zhong Min Cen and Xiangna Zhao and Martin Christner and Robin Kobbe and Sebastian Loos and Jun Oh and Liang Yang and Antoine Danchin and George F. Gao and Yajun Song and Yingrui Li and Huanming Yang and Jian Wang and Jian-guo Xu and Mark J. Pallen and Jun Wang and Martin Aepfelbacher and Ruifu Yang},
  journal={The New England journal of medicine},
  volume={365 8},
An outbreak caused by Shiga-toxin–producing Escherichia coli O104:H4 occurred in Germany in May and June of 2011, with more than 3000 persons infected. Here, we report a cluster of cases associated with a single family and describe an open-source genomic analysis of an isolate from one member of the family. This analysis involved the use of rapid, bench-top DNA sequencing technology, open-source data release, and prompt crowd-sourced analyses. In less than a week, these studies revealed that… CONTINUE READING
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